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Table 1 Results of Western blots normalized to wild-type (WT) or vehicle (VEH)-treated groups. TH tyrosine hydroxylase, VGLUT1 vesicular glutamate transporter 1, GAD67 glutamic acid decarboxylase 67, DAT dopamine transporter, DA dopamine, KO knockout, N.A. not applicable. *p < 0.05, compared to WT or VEH groups; Mann-Whitney test. Values are shown as mean ± SEM

From: Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism

 

TH

VGLUT1

GAD67

DAT

WT

1.00 ± 0.05

1.00 ± 0.18

1.00 ± 0.10

1.00 ± 0.04

BTBR

0.80 ± 0.04*

1.20 ± 0.05

0.94 ± 0.08

0.72 ± 0.05*

Fmr1-KO

1.20 ± 0.17

1.05 ± 0.12

1.10 ± 0.08

0.64 ± 0.05*

BTBR + VEH

1.00 ± 0.05

N.A.

N.A.

1.00 ± 0.05

BTBR + DA

1.20 ± 0.07*

N.A.

N.A.

1.00 ± 0.06

Fmr1-KO + VEH

1.00 ± 0.05

N.A.

N.A.

1.00 ± 0.05

Fmr1-KO + DA

0.71 ± 0.07*

N.A.

N.A.

1.15 ± 0.23