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Fig. 5 | Molecular Brain

Fig. 5

From: The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

Fig. 5

Development of single-dose morphine-induced tolerance. The σ2R−/− (KO) mice developed a profound and lasting tolerance to acute administration of morphine (10 nmol, icv). The data are expressed as the mean ± SEM. * Indicates significantly different compared to the effects induced by the morphine priming dose (30 min) in wild-type (WT) and σ2R−/− mice; all data were analyzed by pairwise Holm-Sidak multiple comparison tests following ANOVA; p < 0.05

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Molecular Brain

ISSN: 1756-6606