Fig. 1
From: Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity
Translin KO mice exhibit deficits in a postsynaptic PKA-dependent form of long-lasting LTP. a A schematic representation of a hippocampal slice showing the placement of electrodes for field-EPSP recordings in the CA1 stratum radiatum upon stimulation of Schaffer collaterals. b Hippocampal slices from translin KO mice (n = 5; 3 males, 2 females) showed impaired long-lasting LTP induced by spaced 4-train stimulation (four 1 s 100 Hz stimuli delivered 5 min apart) compared to slices from wildtype littermates (n = 5; 1 male, 4 females) (two-way repeated-measures ANOVA, F(1,8) = 34.43, p = 0.00038). c Massed 4-train stimulation (four 1 s 100 Hz trains delivered 5 s apart) elicited long-lasting LTP that was not significantly different between slices from translin KO mice (n = 5; 2 males, 3 females) and wildtype littermates (n = 5; 1 male, 4 females) (two-way repeated-measures ANOVA, F(1,8) = 0.923, p = 0.365). Representative traces before (black) and after (red) stimulation are shown on top of each graph. Scale bars for traces 2 mV, 2 ms. ‘n’ refers to the number of mice used. Error bars reflect S.E.M