Table 1 Major pathways altered in SCA3 models
From: Neurodegenerative phosphoprotein signaling landscape in models of SCA3
Pathway | Altered members |
|---|---|
PI3K cell survival pathway | AKT, PTEN, p70S6K, GSK3, RPS6 |
Cell fate pathways | AKT, PTEN, JNK, ERK, GSK3, Src, p53, eNOS, p70S6K, RPS6, caspases 3, caspase 7, caspase 9 |
Apoptotic regulation | Bax, Bcl-xL, XIAP |
Transcriptional regulation | STAT1, STAT3, IκBα |
Pro-survival ERK-p70S6K pathway | ERK, p70S6K, RPS6 |
AKT/mTOR pathway targets | ERK, eNOS, GSK3, p53, p70S6K, PTEN, RPS6, Src |