Fig. 2From: Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer’s disease animal modelRelative abundance of metabolites in the hippocampus in 5xFAD mice at each age. a nicotinamide, b AMP, c LysoPC (16:0), d LysoPC (18:0), and e LysoPE (16:0). Data are shown as means ± SEM of at least 3 independent experiments; 6 M-WT (n = 9), 6 M-5xFAD (n = 9), 8 M-WT (n = 6), 8 M-5xFAD (n = 7), 12 M-WT (n = 9), and 12 M-5xFAD (n = 8). *q < 0.05 compared with age-matched WT mice. AMP, adenosine monophosphate; LysoPC, lysophosphatidylcholine; LysoPE, lysophosphatidylethanolamineBack to article page