Fig. 2
From: SGTA associates with intracellular aggregates in neurodegenerative diseases
SGTA colocalized with neuronal intranuclear inclusions (NIIs) in postmortem brain sections of polyQ diseases. a Upper panels show immunohistochemistry of frozen brain sections of wild type (left) and R6/2 (right) mice using anti-SGTA antibody. Scale bars = 10 μm. Lower panels show double immunostaining images of the CA1 region in the hippocampus of the R6/2 mouse (left: ubiquitin, middle: SGTA, right: merged). Scale bars = 20 μm. b Immunohistochemistry with anti-SGTA antibody in the pontine nucleus of postmortem tissue from patients with polyQ diseases (spinocerebellar ataxias [SCA1, SCA2, SCA3] and dentatorubral–pallidoluysian atrophy [DRPLA]). NIIs indicated by arrow. Scale bar = 20 μm. c Double immunohistochemical labeling with the anti-polyQ antibody (green) and anti-SGTA antibody (red) in the pontine nucleus of postmortem tissue from a patient with SCA1. The nuclei were stained with DAPI. Scale bar = 20 μm