Fig. 7

Distribution of kinetics and receptor ratios in pyramidal neurons and interneurons in the ACC. A A 3-variable distribution plot illustrating the spread of rise and decay time kinetics with peak amplitude in all pyramidal cells (left) and the same plot over a log2 scale for better visualization (n = 24 neurons, 23 mice, 190 channels). B A rise and decay time plot for only monosynaptic responses (left; n = 16 neurons) and polysynaptic responses (right; n = 8 neurons). C A plot showing the ratio of AMPA to KA receptors which contribute to monosynaptic responses (left; n = 8 neurons, 6 mice, 110 channels) and the same plot showing the AMPA to NMDA receptor ratio (right; n = 5 neurons, 3 mice, 28 channels). D A 3-variable distribution plot illustrating the spread of rise and decay time kinetics with peak amplitude (left) and a 3-variable distribution plot illustrating the ratio of AMPA to KA receptors with peak amplitude (right) for FS-INs (n = 42 channels, 3 mice). E Illustrates the same type of data was gathered for fast-spiking interneurons as (C) with RS-INs (n = 20 channels, 2 mice). Both FS INs and RS INs have statistically higher decay times than pyramidal neurons and while FS INs show the highest decay time, it is statistically insignificant relative to RS INs (PN Mono: 16.4 ± 0.7 ms; PN Poly: 22.2 ± 1.9 ms; FS IN: 35.5 ± 5.2 ms; RS IN: 29.6 ± 4.7 ms; **p < 0.01; one-way ANOVA; error bars represent SEM)