Fig. 2
From: Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation
Cocaine induced mitochondrial-related nuclear gene expression in NAc of rodents and human subjects. A Male mice treated with 7 days of cocaine (20 mg/kg, i.p.) display higher mRNA expression of Nrf1, Nrf2, and Tomm20 genes 24 h in NAc. Student’s t-test, *p < 0.05, ***p < 0.001; n = 6 saline and n = 7 cocaine group. B Male rat mRNA expression in NAc tissue after 10 days self-administration (upper panel) followed by 24 h abstinence. Bottom panel: increased expression of Nrf1, Tfb1 and Tomm20 in NAc of rats that self-administer cocaine compared to saline. Student’s t test, *p < 0.05; n = 5 saline and n = 6 cocaine. C mRNA expression in human postmortem NAc tissue indicated that Nrf2 and PGC1α gene expression is higher in human cocaine dependents compared to control subjects. Student’s t test, *p < 0.05; n = 15 control (14 male; 1 female) and n = 15cocaine dependent (14 male;1 female); Error bars, SEM